Following is a list of recent publications from UConn faculty that either contained or discussed data collected at the UConn Health Center NMR Structural Biology Facility. Links to PubMed abstracts and Journal download sites are provided where available. Articles are listed alphabetically according to the first author's surname.


2007 Publications


  1. Stern AS, Donoho DL, Hoch JC.(2007) NMR data processing using iterative thresholding and minimum l(1)-norm reconstruction. J Magn Reson , Aug 3; [Epub ahead of print]
    PubMed | Journal

  2. Mobli M, Maciejewski MW, Gryk MR, Hoch JC. (2007) Automatic maximum entropy spectral reconstruction in NMR. J Biomol NMR, Oct;39(2):133-9.
    PubMed | Journal

  3. Mobli M, Maciejewski MW, Gryk MR, Hoch JC. (2007) An automated tool for maximum entropy reconstruction of biomolecular NMR spectra. Nat Methods. 42, Jun;4(6):467-8.
    PubMed | Journal

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2006 Publications


  1. Balla S, Thapar V, Verma S, Luong T, Faghri T, Huang CH, Rajasekaran S, del Campo JJ, Shinn JH, Mohler WA, Maciejewski MW, Gryk MR, Piccirillo B, Schiller SR, Schiller MR.(2006) Minimotif Miner: a tool for investigating protein function. Nat Methods. 3(3) ,175-7.
    PubMed | Journal

  2. Jordan JB, Kovacs H, Wang Y, Mobli M, Luo R, Anklin C, Hoch JC, Kriwacki RW. (2006) Three-dimensional 13C-detected CH3-TOCSY using selectively protonated proteins: facile methyl resonance assignment and protein structure determination. J Am Chem Soc. , Jul 19;128(28):9119-28
    PubMed | Journal

  3. Mobli M, Stern AS, Hoch JC. (2006) Spectral reconstruction methods in fast NMR: reduced dimensionality, random sampling and maximum entropy. J Magn Reson. , Sep;182(1):96-105.
    PubMed | Journal

  4. Frueh DP, Sun ZY, Vosburg DA, Walsh CT, Hoch JC, Wagner G. (2006) Non-uniformly sampled double-TROSY hNcaNH experiments for NMR sequential assignments of large proteins. J Am Chem Soc. , May 3;128(17):5757-63.
    PubMed | Journal

  5. Gorbatyuk VY, Nosworthy NJ, Robson SA, Bains NP, Maciejewski MW, Dos Remedios CG, King GF. (2006) Mapping the phosphoinositide-binding site on chick cofilin explains how PIP2 regulates the cofilin-actin interaction. Mol Cell., Nov 17;24(4):511-22.
    PubMed | Journal

  6. Schiller MR, Chakrabarti K, King GF, Schiller NI, Eipper BA, Maciejewski MW. (2006) Regulation of RhoGEF activity by intramolecular and intermolecular SH3 domain interactions. J Biol Chem. , Jul 7;281(27):18774-86.
    PubMed | Journal

  7. Loshon CA, Wahome PG, Maciejewski MW, Setlow P. (2006) Levels of glycine betaine in growing cells and spores of Bacillus species and lack of effect of glycine betaine on dormant spore resistance. J Bacteriol. , Apr;188(8):3153-8.
    PubMed | Journal

  8. Escoubas P, Sollod B, King GF. (2006) Venom landscapes: mining the complexity of spider venoms via a combined cDNA and mass spectrometric approach. Toxicon. , May;47(6):650-63.
    PubMed | Journal

  9. Mukherjee AK, Sollod BL, Wikel SK, King GF. (2006) Orally active acaricidal peptide toxins from spider venom. Toxicon. , Feb;47(2):182-7.
    PubMed | Journal

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2005 Publications


  1. Sun ZY, Frueh DP, Selenko P, Hoch JC, Wagner G. (2005) Fast assignment of 15N-HSQC peaks using high-resolution 3D HNcocaNH experiments with non-uniform sampling. J Biomol NMR.Sep;33(1):43-50.
    PubMed | Journal

  2. Teilum K, Hoch JC, Goffin V, Kinet S, Martial JA, Kragelund BB. (2005) Solution structure of human prolactin. J Mol Biol. Aug 26;351(4):810-23.
    PubMed | Journal

  3. Sun ZY, Hyberts SG, Rovnyak D, Park S, Stern AS, Hoch JC, Wagner G. (2005) High-resolution aliphatic side-chain assignments in 3D HCcoNH experiments with joint H-C evolution and non-uniform sampling. J Biomol NMR. May;32(1):55-60.
    PubMed | Journal

  4. Robson SA, Gorbatyuk VY, Maciejewski MW, King GF. (2005) Backbone and side-chain 1H, 15N, and 13C assignments for the beta domain of the bacterial cell division protein DivIB. J Biomol NMR. Mar;31(3):261-2.
    PubMed | Journal

  5. Wu H, Maciejewski MW, Takebe S, King SM. (2005) Solution structure of the Tctex1 dimer reveals a mechanism for dynein-cargo interactions. Structure. Feb;13(2):213-23.
    PubMed | Journal

  6. Robson SA, King GF. (2005) Backbone and side-chain 1H, 15N and 13C assignments for the cis conformer of the beta domain of the bacterial cell division protein DivIB. J Biomol NMR. Oct;33(2):135.
    PubMed | Journal

  7. Sollod BL, Wilson D, Zhaxybayeva O, Gogarten JP, Drinkwater R, King GF. (2005) SWere arachnids the first to use combinatorial peptide libraries? Peptides. Jan;26(1):131-9.
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2004 Publications


  1. Fox-Erlich S, Martyn TO, Ellis HJ, Gryk MR.(2004) Delineation and analysis of the conceptual data model implied by the "IUPAC Recommendations for Biochemical Nomenclature". Protein Sci. 2559-63.
    PubMed | Journal

  2. Shimba N, Kovacs H, Stern AS, Nomura AM, Shimada I, Hoch JC, Craik CS, Dotsch V. (2004) Optimization of 13C direct detection NMR methods. J Biomol NMR. , Oct;30(2):175-9.
    PubMed | Journal

  3. Rovnyak D, Hoch JC, Stern AS, Wagner G. (2004) Resolution and sensitivity of high field nuclear magnetic resonance spectroscopy. J Biomol NMR. , Sep;30(1):1-10.
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2003 Publications


  1. Marintchev, A., Gryk, M.R. and Mullen, G.P. (2003) Site-directed mutagenesis analysis of the structural interaction of the single-strand-break repair protein, X-ray cross-complementing group 1, with DNA polymerase beta.
    Nucleic Acids Research 31, 580-588.
    PubMed | Journal

  2. Wu, H. and King, S.M. (2003) Backbone dynamics of dynein light chains (review). Cell Motility and the Cytoskeleton, in press.
    PubMed | Journal

  3. Wu, H., Blackledge, M., Maciejewski, M.W., Mullen, G.P. and King, S.M. (2003) Relaxation-based structure refinement and backbone molecular dynamics of the dynein motor domain-associated light chain. Biochemistry 42, 57-71.
    PubMed | Journal

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2002 Publications


  1. Albert, A.D. and Yeagle, P.L. (2002) Structural studies on rhodopsin (review). Biochimica et Biophysica Acta 1565, 183-195.
    PubMed | Journal

  2. Bains, N.P., Gorbatyuk, V.Ya., Nosworthy, N.J., Robson, S.A., Maciejewski, M.W., dos Remedios, C.G. and King, G.F. (2002) Backbone and side-chain 1H, 15N, and 13C assignments for chick cofilin. Journal of Biomolecular NMR 22, 193-194.
    PubMed | Journal

  3. Choi, G., Landin, J., Galan, J.F., Birge, R.R., Albert, A.D. and Yeagle PL. (2001) Structural studies of metarhodopsin II, the activated form of the G-protein coupled receptor, rhodopsin. Biochemistry 41, 7318-7324.
    PubMed | Journal

  4. Gryk, M.R., Maciejewski, M.W., Robertson, A., Mullen, M.A., Wilson, S.H. and Mullen, G.P. (2002) 1H, 13C and 15N resonance assignments for the perdeuterated 22 kD palm-thumb domain of DNA polymerase beta. Journal of Biomolecular NMR 22, 197-198.
    PubMed | Journal

  5. Gryk, M.R., Marintchev, A., Maciejewski, M.W., Robertson, A., Wilson, S.H. and Mullen, G.P. (2002) Mapping of the interaction interface of DNA polymerase beta with XRCC1. Structure 10, 1709-1720.
    PubMed | Journal

  6. King, G.F., Tedford, H.W. and Maggio, F. (2002) Structure and function of insecticidal neurotoxins from Australian funnel-web spiders (review). Journal of Toxicology - Toxin Reviews 21, 361-389.
    PubMed | Journal

  7. Maggio, F. and King, G.F. (2002) Scanning mutagenesis of a Janus-faced atracotoxin reveals a bipartite surface patch that is essential for neurotoxic function. Journal of Biological Chemistry 277, 22806-22813.
    PubMed | Journal

  8. Mosavi, L., Minor Jr., D. and Peng, Z. (2002) Consensus derived structural determinants of the ankyrin repeat motif. Proceedings of the National Academy of Sciences USA 99, 16029-16034.
    PubMed | Journal

  9. Mosavi, L.K., Williams, S. and Peng, Z.Y. (2002) Equilibrium folding and stability of myotrophin: a model ankyrin repeat protein. Journal of Molecular Biology 320, 165-170.
    PubMed | Journal

  10. Robson, S.A., Michie, K.A., Mackay J.P., Harry, E. and King, G.F. (2002) The Bacillus subtilis cell division proteins FtsL and DivIC are intrinsically unstable and do not interact with one another in the absence of other septasomal components. Molecular Microbiology 44, 663-674.
    PubMed | Journal

  11. Shih, Y.-L., Fu, X., King, G.F., Le, T. and Rothfield, L.I. (2002) Division-site placement in E. coli: mutants that prevent formation of the MinE ring lead to loss of the normal midcell arrest of growth of polar MinD membrane domains. EMBO Journal 21, 3347-3357.
    PubMed | Journal

  12. Szeto, T.H., Rowland, S.L., Rothfield, L.I. and King, G.F. (2002) Membrane localization of MinD is mediated by a C-terminal motif that is conserved across eubacteria, archaea, and chloroplasts. Proceedings of the National Academy of Sciences USA 99, 15693-15698.
    PubMed | Journal

  13. Yeagle, P.L. and Albert, A.D. (2002) Use of nuclear magnetic resonance to study the three-dimensional structure of rhodopsin. Methods in Enzymology 343, 223-231.
    PubMed | Journal

  14. Zhang, B. and Peng, Z.Y. (2002) Structural consequences of tumor-derived mutations in p16INK4a probed by limited proteolysis. Biochemistry 41, 6293-6302.
    PubMed | Journal

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2001 Publications


  1. Alexandrescu, A.T. (2001) An NMR-based quenched hydrogen exchange investigation of model amyloid fibrils formed by cold shock protein A. Pacific Symposium on Biocomputing 6, 67-78.
    PubMed | Journal

  2. Alexandrescu, A.T., Maciejewski, M.W., Ruegg, M.A., Engel, J. and Kammerer, R.A. (2001) 1H, 13C and 15N backbone assignments for the C-terminal globular domain of agrin. Journal of Biomolecular NMR 20, 295-296.
    PubMed | Journal

  3. Bai, P. and Peng, Z. (2001) Cooperative folding of the isolated alpha-helical domain of hen egg white lysozyme.  Journal of Molecular Biology 314, 321-329.
    PubMed | Journal

  4. Bai, P., Song, J., Luo, L. and Peng, Z.Y.(2001) A model of dynamic sidechain-sidechain interactions in the alpha-lactalbumin molten globule. Protein Science 10, 55-62.
    PubMed | Journal

  5. Hayes, C.S., Alarcon-Hernandez, E. and Setlow P. (2001) N-terminal amino acid residues mediate protein-protein interactions between DNA-bound alpha/beta-type small, acid-soluble spore proteins from Bacillus species. Journal of Biological Chemistry 276, 2267-2275.
    PubMed | Journal

  6. Katragadda, M., Alderfer, J.L. and Yeagle, P.L. (2001) Assembly of a polytopic membrane protein structure from the solution structures of overlapping peptide fragments of bacteriorhodopsin. Biophysical Journal 81, 1029-1036.
    PubMed | Journal

  7. Katragadda, M., Chopra, A., Bennett, M., Alderfer, J.L., Yeagle, P.L,. and Albert, A.D. (2001) Structures of the transmembrane helices of the G-protein coupled receptor, rhodopsin. Journal of Peptide Research 58, 79-89.
    PubMed | Journal

  8. Maciejewski, M.W., Pan, B., Shin, R., Denninger, A. and Mullen, G.P. (2001) 1H, 15N, and 13C resonance assignments for a 20 kDa DNA polymerase from African swine fever virus. Journal of Biomolecular NMR 21, 177-178.
    PubMed | Journal

  9. Maciejewski, M.W., Shin, R., Pan, B., Marintchev, A., Denninger, A., Mullen, M.A., Kang, C., Gryk, M.R. and Mullen, G.P. (2001) Solution structure of a viral DNA repair polymerase.  Nature Structural Biology 8, 936-941.
    PubMed | Journal | News & Views

  10. Pan, B., Maciejewski, M.W., Marintchev, A. and Mullen, G.P. (2001) Solution structure of the catalytic domain of gamma delta resolvase. Implications for the mechanism of catalysis. Journal of Molecular Biology 310, 1089-1107.
    PubMed | Journal

  11. Szeto, T.H. , Rowland, S.L. and King, G.F. (2001) The dimerization function of MinC residues in a structurally autonomous C-terminal domain. Journal of Bacteriology 183, 6684-6687.
    PubMed | Journal | Front Cover

  12. Tedford, H.W., Fletcher, J.I. and King, G.F. (2001) Functional significance of the beta hairpin in the insecticidal neurotoxin omega-atracotoxin-Hv1a. Journal of Biological Chemistry 276, 26568-26576.
    PubMed | Journal

  13. Wang, X-H., Connor, M., Wilson, D., Wilson, H.I., Nicholson, G.M., Smith, R., Shaw, D., Mackay, J.P., Alewood, P.F., Christie, M.J. and King, G.F. (2001) Discovery and structure of a potent and highly specific blocker of insect calcium channels. Journal of Biological Chemistry 276, 40306-40312.
    PubMed | Journal

  14. Wu, H., Maciejewski, M.W., Benashski, S.E., Mullen, G.P. and King, S.M. (2001) 1H, 15N, and 13C resonance assignments for the Tctex1 dynein light chain from Chlamydomonas flagella. Journal of Biomolecular NMR 20, 89-90.
    PubMed | Journal

  15. Yeagle, P.L., Choi, G. and Albert, A.D. (2001) Studies on the structure of the G-protein-coupled receptor rhodopsin including the putative G-protein binding site in unactivated and activated forms. Biochemistry 40, 11932-11937.
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2000 Publications


  1. Albert, A.D. and Yeagle, P.L. (2000) Domain approach to three-dimensional structure of rhodopsin using high-resolution nuclear magnetic resonance. Methods in Enzymology 315, 107-115.
    PubMed | Journal

  2. Alexandrescu, A.T., Lamour, F.P. and Jaravine, V.A. (2000) NMR evidence for progressive stabilization of native-like structure upon aggregation of acid-denatured LysN. Journal of Molecular Biology 295, 239-255.
    PubMed | Journal

  3. Bai, P., Luo L. and Peng, Z. (2000) Side chain accessibility and dynamics in the molten globule state of alpha-lactalbumin: A 19F NMR study. Biochemistry 39, 372-380.
    PubMed | Journal

  4. Chopra, A., Yeagle, P.L., Alderfer, J.A. and Albert, A.D. (2000) Solution structure of the sixth transmembrane helix of the G-protein-coupled receptor, rhodopsin. Biochimica et Biophysica Acta 1463, 1-5.
    PubMed | Journal

  5. Hayes, C.S., Peng, Z.Y. and Setlow, P. (2000) Equilibrium and kinetic binding interactions between DNA and a group of novel, nonspecific DNA-binding proteins from spores of Bacillus and Clostridium species. Journal of Biological Chemistry 275, 35040-35050.
    PubMed | Journal

  6. Jaravine, V.A., Rathgeb-Szabo, K., Alexandrescu, A.T. (2000) Microscopic stability of cold shock protein A examined by NMR native state hydrogen exchange as a function of urea and trimethylamine N-oxide. Protein Science 9, 290-301.
    PubMed | Journal

  7. Katragadda, M., Alderfer, J.L. and Yeagle, P.L. (2000) Solution structure of the loops of bacteriorhodopsin closely resembles the crystal structure. Biochimica et Biophysica Acta 1466, 1-6.
    PubMed | Journal

  8. King, G.F., Shih, Y.-L., Maciejewski, M.W., Bains, N.P.S., Pan, B., Rowland, S.L., Mullen, G.P. and Rothfield, L.I. (2000) Structural basis for the topological specificity function of MinE. Nature Structural Biology 7, 1013-1017.
    PubMed | Journal | News & Views

  9. Maciejewski, M.W., Liu, D-J., Prasad, R., Wilson, S.H. and Mullen, G.P. (2000) Backbone dynamics and refined solution structure of the N-terminal domain of DNA polymerase beta. Correlation with DNA binding and dRP lyase activity. Journal of Molecular Biology 296, 229-253.
    PubMed | Journal

  10. Wang, X-H., Connor, M., Smith, R., Maciejewski, M.W., Howden, M.E.H., Nicholson, G. M., Christie, M. J. and King, G. F. (2000) Discovery and characterization of a family of insecticidal neurotoxins with a rare vicinal disulfide bond. Nature Structural Biology 7, 505-513.
    PubMed | Journal

  11. Wu, H., Maciejewski, M.W., Marintchev, A., Benashski, S.E., Mullen, G.P. and King, S. M.(2000) Solution structure of a dynein motor domain-associated light chain. Nature Structural Biology 7, 575-579.
    PubMed | Journal

  12. Yeagle, P.L., Danis, C., Choi, G., Alderfer, J.L. and Albert A.D. (2000) Three dimensional structure of the seventh transmembrane helical domain of the G-protein receptor, rhodopsin. Molecular Vision 6, 125-131.
    PubMed | Journal

  13. Yeagle, P.L., Salloum, A., Chopra, A., Bhawsar, N., Ali, L., Kuzmanovski, G., Alderfer, J.L. and Albert, A.D. (2000) Structures of the intradiskal loops and amino terminus of the G-protein receptor, rhodopsin. Journal of Peptide Research 55, 455-465.
    PubMed | Journal

  14. Zhang, B. and Peng, Z. (2000) A minimum folding unit in the ankyrin repeat protein p16. Journal of Molecular Biology 299, 1121-1132.
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1999 Publications


  1. Alexandrescu, A.T. and Rathgeb-Szabo, K. (1999) An NMR investigation of solution aggregation reactions preceding the misassembly of acid-denatured cold shock protein A into fibrils. Journal of Molecular Biology 291, 1191-206.
    PubMed | Journal

  2. Alexandrescu, A.T., Jaravine, V.A., Dames, S.A. and Lamour FP. (1999) NMR hydrogen exchange of the OB-fold protein LysN as a function of denaturant: the most conserved elements of structure are the most stable to unfolding. Journal of Molecular Biology 289, 1041-1054.
    PubMed | Journal

  3. King, G.F., Pan, B., Maciejewski, M.W., Rowland, S.L., Rothfield, L.I. and Mullen, G.P. (1999) Backbone and side-chain 1H, 15N, and 13C assignments for the topological specificity domain of the MinE cell division protein. Journal of Biomolecular NMR 13, 395-396.
    PubMed | Journal

  4. King, G.F., Rowland, S.L., Pan, B., Mackay, J.P., Mullen, G.P. and Rothfield, L.I. (1999) The dimerization and topological specificity functions of MinE reside in a structurally autonomous C-terminal domain. Molecular Microbiology 31, 1161-1170.
    PubMed | Journal

  5. Marintchev, A., Maciejewski, M.W. and Mullen, G.P. (1999) 1H, 15N, and 13C Resonance assignments for the N-terminal 20 kDa domain of the DNA single-strand break repair protein XRCC1. Journal of Biomolecular NMR 13, 393-394.
    PubMed | Journal

  6. Marintchev, A., Mullen, M.A., Maciejewski, M.W., Pan, B., Gryk, M.R. and Mullen, G.P. (1999) Solution structure of the single-strand break repair protein XRCC1-N-terminal domain. Nature Structural Biology 6, 884-893.
    PubMed | Journal | News & Views | Front Cover

  7. Pan, B. and Mullen, G.P. (1999) 1H, 15N, and 13C resonance assignments for the catalytic core of gamma delta resolvase. Journal of Biomolecular NMR 13, 307-308.
    PubMed | Journal

  8. Wu, H., Maciejewski, M.W., Benashski, S.E., Mullen, G.P. and King, S.M. (1999) 1H, 15N, and 13C resonance assignments for the 22 kDa LC1 light chain from Chlamydomonas outer arm dynein. Journal of Biomolecular NMR 13, 309-310.
    PubMed | Journal

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