The Nuclear Magnetic Resonance (NMR) Structural Biology Facility at UConn Health Center provides a state-of-the-art environment for studying the three-dimensional structure, dynamics, folding, and interactions of biological macromolecules. The primary goal of the facility is the application of advanced NMR techniques to important and challenging biomedical problems. To meet these challenges, facility staff develop new methods to enhance and facilitate bio-molecular applications of NMR. In addition to providing access to state-of-the-art instrumentation for experienced users, the facility provides support for new users interested in bio-molecular applications of NMR.